Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
نویسندگان
چکیده
The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects platinum-doped magnesia (Pt/MgO) nanoparticles. chemical compositions, functional groups, size nanoparticles were determined using X-ray diffraction, Fourier transform infrared spectroscopy, energy dispersive transmission electron microscopy, scanning microscopy. Pt/MgO cuboid nanosize range 30–50 nm. cytotoxicity via 3-(4,5-dimethylthiazol-2-yl)?2,5-diphenyltetrazolium bromide assay on human lung colonic cancer cells (A549 HT29 respectively) normal fibroblasts (MRC-5 CCD-18Co repectively). relatively innocuous cells. downregulated Bcl-2 upregulated Bax p53 tumor suppressor proteins also induced production reactive oxygen species, decreased cellular glutathione level, increased lipid peroxidation. Thus, attributed induction oxidative stress apoptosis. showed potential as an anti-cancer compound.
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2021
ISSN: ['0753-3322', '1950-6007']
DOI: https://doi.org/10.1016/j.biopha.2021.111483